1655 Levosimendan and Milrinone: A Safe Combination?
نویسندگان
چکیده
منابع مشابه
Levosimendan versus milrinone for pediatric cardiac surgery
BACKGROUND: Our aim is to check effectiveness of intravenous Levosimendan in comparison with intravenous Milrinone in congenital heart surgery with cardiopulmonary bypass. MATERIALS AND METHODS: 50 Paediatric patients between 2 months to 12 years of age divided into two groups. Group L (n=25) received inj. levosimendan 12μg/kg over 10 minutes1 after cross clamp removal and 0.1μg/kg/min started ...
متن کاملMilrinone and levosimendan administered after reperfusion improve myocardial stunning in swine.
OBJECTIVES We assessed the effect of milrinone application timing after reperfusion against myocardial stunning as compared with levosimendan in swine. Furthermore, we examined the role of p38 mitogen-activated protein kinase (p38 MAPK) in the milrinone-induced cardioprotection. DESIGN All swine were subjected to 12-minutes ischemia followed by 90-minutes reperfusion to generate stunned myoca...
متن کاملEffects of Combined Milrinone and Levosimendan Treatment on Systolic and Diastolic Function During Postischemic Myocardial Dysfunction in a Porcine Model.
It is not known whether there are positive or negative interactions on ventricular function when a calcium-sensitizing inotrope is added to a phosphodiesterase inhibitor in the clinical setting of acute left ventricular (LV) dysfunction. We hypothesized that when levosimendan is added to milrinone treatment, there will be synergetic inotropic and lusitropic effects. This was tested in an anesth...
متن کاملHyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts
BACKGROUND The authors examined whether milrinone and levosimendan could exert cardiac postconditioning effects in rats under normoglycemia and hyperglycemia, and whether the effects could be mediated by mitochondrial permeability transition pore (mPTP). METHODS Wistar rats underwent 30-min coronary artery occlusion followed by 2-h reperfusion. The rats received milrinone or levosimendan just...
متن کاملThe effects of levosimendan in cardiac surgery patients with poor left ventricular function.
BACKGROUND Patients with poor left ventricular function often require inotropic drug support immediately after cardiopulmonary bypass. Levosimendan improves cardiac function by a novel mechanism of action compared to currently available drugs. We hypothesized that, in patients with severely compromised ventricular function, the use of levosimendan would be associated with better postoperative c...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 2012
ISSN: 0003-9888,1468-2044
DOI: 10.1136/archdischild-2012-302724.1655